Pavle Mihajlović

I am a second year UCSD student, majoring in Pharmacological Chemistry

JAK inhibitors: New Delays by FDA

During the past couple of weeks, three large companies, AbbVie, Lilly, and Pfizer have recieved requests by the FDA that essentially delay the approval of their atopical dermatitis drugs that function as JAK inhibitors (1). Pfizer has been developing abrocitinib, an oral drug that is a selective JAK inhibitor and is designed for treatment of …

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JAK Inhibitor Upadacitinib Repurpoused as a Potential Psoriatic Arthritis Treatment

AbbVie has recently come out with updates on applications of Rinvoq, generic name upadacitinib, which has already been approved as a secondary rheumatoid arthritis treatment in 2019. The new updates highlight the potential of the drug as a secondary psoriatic arthritis (PsA) treatment when other approved treatments have proven to be underwhelming. 

The Better Future of Chemotherapy: Myeloprotection Therapy for Small-Cell Lung Cancer

Bone marrow suppression is a virtually ubiquitous side effect of chemotherapy that limits the dose of the chemo drug. However, a new drug, trilaciclib, can make this a problem of the past. The drug, trade name Cosela, is being developed by G1 Theraputics, and has already been approved for use by the FDA for patients …

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New NSAID That Is Easier on the Stomach: Antibe Theraputics IND Application Approved by FDA

The Non Steroidal Anti Inflammatory Drug (NSAID) class is present in virtually every household and first aid kit. However, widely-popular drugs like aspirin, ibuprofen, and naproxen have issues concerning their gastrointestinal safety, leading to an increased risk of gastrointestinal ulcers and bleeds. The company Antibe Theraputics are developing a drug derivative of naproxen, called Otenaproxesul, …

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Albomycins: An unexplored group with potential to be the future of antibiotics?

The idea of the “magic bullet” that perfectly breaches only target cells and proceeds to kill them, has long been the fantasy of pharmacology. This fantasy is being brought closer to reality every year, and the research on albomycin compounds shows definite progress towards this end goal. And new research shows that there is more …

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